You will find the questions attached 5.1 For the survival times given in Table 3.1, compare the survival distributions of the two treatment

5.2 For the remission data given in Table 3.1, compare the remission time
distributions of the two treatment groups using
(a) The logrank test
(b) The Peto and Peto’s generalized Wilcoxon test
Exercise 4.5 the following remission times of 42 patients with acute leukemia reported byFreireich et al. (1963)* in a clinical trial to assess the efficacy of 6-mercaptopurine (6-MP)to maintain remission. The patients were randomized to receive 6-MP or a placebo. Thestudy was terminated after 1 year and the following remission times, in weeks, wererecorded: 6- MP(21 patients) : 6, 6, 6, 7, 10, 13, 16, 22, 23, 6+, 94, 10+, 11+, 17+, 19+, 20+,25+, 32+, 32+, 34+, 35+ Placebo (21 patients) : 1, 1, 2, 2, 3, 4, 4, 5, 5, 8, 8, 8, 8, 11, 11, 12,12, 15, 17, 22, 23
5.5 Consider the remission time in Exercise 4.5. Use the logrank test and the generalizedWilcoxon test to test the equality of the two treatments.
5.6 For the first four skin tests given in Exercise Table 3.1, use the Cox-Mantel test and thelogrank test to see if there is a significant difference in survival between patients withpositive (25×5 mm for mumps, ≥10 x 10 mm for others) and negative (

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